The influence of gut microbiota on the progression, maintenance, and control of sepsis: A Comprehensive Review

Influence of gut microbiota on the control of sepsis

Abstract

Background: Sepsis is a medical condition that characterized by an unbalanced immune response to an infection, leading to an organ damage. The dysfunction of gut microbes due to sepsis have significant impact on body organs and tissues. Several therapies include fecal microbiota transplantation, dietary fiber intake and antibiotic scavengers which reduce the impact of antimicrobial agents on gut microbiota while enhancing their presence at main infection sites.

Objective: The aim of this review is to explore recent development in the field, evaluate microbiota based therapeutic options, and highlights the need of further research to evaluate their role in sepsis management.

Methods: A comprehensive search of databases, including PubMed, Scopus, and Web Science was conducted to identify relevant studies published up to 2023. The inclusion criteria covered clinical trials and observational studies assessing the effect of fecal microbiota transplantation, probiotics and prebiotics, postbiotics, synbiotics and antibiotics in sepsis management.

Results: The review included studies that have beneficial impact of prebiotics, probiotics, fecal microbiota transplantation on sepsis. Specifically, these interventions were found to improve intestine barrier characteristics, restore intestine microbial variety and decrease infection.

Conclusion: The gut microbiota plays a crucial role in sepsis pathogenesis, affecting immune responses, gut barrier function, and bacterial translocation. Modulating the gut microbiota through various therapeutic interventions holds promise in sepsis management. However, further research is required to fully understand the underlying mechanisms and optimize treatment strategies for personalized care.

Keywords: Sepsis, Gut microbiota, Probiotics, Fecal microbiota transplant,